Table 1.

Inhibitors targeting various stages of herpesvirus life cycle.

Drugs	Virus	Life cycle events
Compound SP-510-50 PI3K inhibitor: Idelalisib NVP-BEZ235 Dermaseptins Endocytosis inhibitor: Chlorpromazine anti-gHgL antibodies: CL40 and CL59 Amantadine analog: Tromantadine Saturated fatty alcohol: Docosanol	HSV-1 HSV-2, HCMV KSHV, EBV HSV-1, HSV-2, EBV KSHV, EBV EBV EBV HSV-1	Virus binding or entry inhibitors
Epigenetic therapy
DNMT inhibitors: 5-azacytidine, RG108 HDAC inhibitors: MC1568, Sodium butyrate, Trichostatin A (TSA), Vorinostat (SAHA), Valproic Acid HMT inhibitors: DZNep (EZH2i) GSK126, GSK343 HDM inhibitors: ML342, DMOG, OG-L002, TCP	HSV-1, HSV-2, HCMV, VZV, EBV, KSHV HSV-1, HCMV HSV-1 HSV-1	Repression of viral immediate early gene expression. Production of infectious progeny in quiescently infected cells. Latency reversal Significant activation of the lytic transcriptional program in HCMV Blockage of lytic HSV-1 replication in latently infected ganglion explant model Repression of viral IE gene expression
Nucleoside analogs
Trifluridine, Edoxudine, Brivudine, Cytarabine, Cidofovir, Acyclovir Ganciclovir, Penciclovir, Virdarabine, Indoxuridine Non-nucleoside inhibitors: Foscarnet PNU-183792 NSC 373989 Helicase-primase inhibitor: BAY 57-1293 T-0902611 BILS 179BS Protein-protein interaction inhibitor BILD1263	HSV-1, HSV-2, VZV, HCMV, EBV, HHV-6, HHV-7, KSHV HSV-1, HSV-2, VZV, HCMV HSV, VZV, HCMV KSHV HSV-1, HSV-2 HCMV HSV-1, HSV-2 HSV-1	DNA synthesis inhibitor. These drugs competitively stop the incorporation of dNTPs by the viral DNA polymerase and thereby end the elongation of viral DNA DNA synthesis inhibitors. Inhibit progression of the replication fork Inhibits viral replication
Pyrazolo
Quinoline, Benzothiophene Phosphorothioate oligonucleotides	HSV-1 HCMV, EBV, KSHV	Gene expression
Acridones, Thiourea inhibitors Phenylenediamine: Sulfonamides Ribosylbenzimidazoles	HSV, EBV HCMV, KSHV HCMV	Assembly or egress