Table 2.
Cellular protein kinase tested for anti-herpesvirus associated cancers.
| Drug | Virus | Primary targets | Ref |
|---|---|---|---|
| Chk2 inhibitor II | HSV | Chk2 | (Alekseev et al., 2015) |
| Roscovitine (seliciclib) | HSV, VZV, HCMV and EBV | CDKs | (Schang et al., 2002; Kudoh et al., 2004; Taylor et al., 2004; Shin et al., 2008) |
| Purvalanol A | HSV, VZV and EBV | (Schang et al., 2002; Kudoh et al., 2004; Moffat et al., 2004) | |
| Olomoucine II | HSV and HCMV | (Moffat et al., 2004) | |
| Indirubin-3’-monoxime | HCMV | GSK3β | (Hertel et al., 2007) |
| Torin1 | HSV and HCMV | mTOR | (Li and Hayward, 2013) |
| Everolimus | HCMV, EBV | (Poglitsch et al., 2012; Rittà et al., 2015) | |
| Letermovir | HCMV | Terminus inhibitor | (Gerna et al., 2019) |
| Maribavir | HCMV | UL97 viral protein kinase | (Papanicolaou et al., 2019) |
| KU55933 | HSV, HCMV and EBV | Ataxia telangiectasia mutated (ATM) | (Hagemeier et al., 2012; Costa et al., 2013; Alekseev et al., 2014) |
| TBB | HSV-1 and EBV | Casein kinase 2 (CK2) | (Medina-Palazon et al., 2007; Smith et al., 2011) |
| DMAT | |||
| TMCB | |||
| SP600125 | VZV | c-Jun N-terminal kinase (JNK) | (Zapata et al., 2007) |
| Gleevec (imatinib mesylate) | HCMV, KSHV | Inhibits multiple tyrosine kinases | (Soroceanu et al., 2008; Koon et al., 2014) |
| Sorafenib (BAY 43-9006) | PDGFR and Raf kinases | (Michaelis et al., 2011) | |
| STO-609 | Calmodulin-dependent kinase kinase (CaMKK) | (McArdle et al., 2011; McArdle et al., 2012) | |
| LY294002 | PI3K | (Johnson et al., 2001a) | |
| U-0126 | HCMV and EBV | MEK1/2 | (Johnson et al., 2001b; Goswami et al., 2012) |
| Flavopiridol (alvocidib) | EBV | CDKs | (Goswami et al., 2012) |
| Kenpaullone | GSK3β, LcK | (Goswami et al., 2012) | |
| Dasatinib | Inhibits multiple tyrosine kinases | (Chakraborty et al., 2012; Goswami et al., 2012; Hahn et al., 2012) | |
| K252A | |||
| BAY 11-7082 | Inhibitor of κB kinase (IKK) | (Goswami et al., 2012) | |
| Wortmannin | Phosphatidylinositol-3-kinase (PI3K) | (Goswami et al., 2012) | |
| PCI-32765 | Bruton’s tyrosine kinase (Btk) | (Zocchi et al., 2018) | |
| MLN8237 | Aurora A kinase | (Iankov et al., 2015) | |
| CCI-779 (temsirolimus) | mTOR | (Kawada et al., 2014) | |
| BI-D1870 | p90 ribosomal S6 kinases (RSKs) | (Kuang et al., 2008) | |
| SU5416 | VEGFR tyrosine kinase | (Aoki and Tosato, 2004) |