Table 3. Allogeneic Blood Component Transfusions.
| Variable | PCC group | FP group | PCC:FP ratio (2-sided 95% CI) of LS mean | P value | ||||
|---|---|---|---|---|---|---|---|---|
| No. of patients | Median (IQR), U | LS mean (CI), U | No. of patients | Median (IQR), U | LS mean (CI), U | |||
| Cumulative allogeneic blood components within 24 h after start of surgerya | ||||||||
| RBC + platelet + FP (including IMP) | 54 | 6.0 (4.0-11.0) | 8.7 (7.2-10.5) | 47 | 14.0 (8.0-20.0) | 14.8 (12.3-17.9) | 0.58 (0.45-0.77) | <.001 |
| RBC + platelet + FP (excluding IMP) | 54 | 6.0 (4.0-11.0) | 8.6 (7.0-10.6) | 47 | 10.0 (6.0-16.0) | 10.8 (8.6-13.4) | 0.80 (0.59-1.08) | .15 |
| Individual allogeneic blood components within 24 h after start of surgery | ||||||||
| FP (including IMP) | 54 | 0 | 0.3 (0.2-0.4) | 47 | 4.0 (3.0-4.0) | 4.4 (3.6-5.3) | 0.06 (0.03-0.11) | <.001 |
| Platelet | 54 | 4.0 (4.0-8.0) | 6.2 (5.1-7.6) | 47 | 8.0 (4.0-12.0) | 7.2 (5.9-8.9) | 0.86 (0.64-1.15) | .30 |
| Red blood cell | 54 | 1.5 (0.0-4.0) | 2.2 (1.7-2.9) | 47 | 3.0 (1.0-5.0) | 3.2 (2.5-4.2) | 0.69 (0.47-0.99) | .05 |
| Cumulative allogeneic blood components within 24 h after CPBb | ||||||||
| RBC + platelet + FP (including IMP) | 54 | 5.0 (4.0-9.0) | 7.5 (6.2-9.1) | 47 | 12.0 (7.0-19.0) | 13.4 (11.1-16.2) | 0.56 (0.43-0.73) | <.001 |
| RBC + platelet + FP | 54 | 5.0 (4.0-9.0) | 7.4 (6.0-9.2) | 47 | 8.0 (4.0-15.0) | 9.5 (7.6-11.8) | 0.78 (0.58-1.06) | .11 |
| Individual allogeneic blood components within 24 h after CPB | ||||||||
| FP (including IMP) | 54 | 0 | 0.3 (0.2-0.4) | 47 | 4.0 (2.0-4.0) | 4.2 (3.4-5.1) | 0.06 (0.03-0.11) | <.001 |
| Platelet | 54 | 4.0 (4.0-8.0) | 5.9 (4.8-7.3) | 47 | 8.0 (4.0-12.0) | 6.7 (5.4-8.4) | 0.88 (0.65-1.19) | .40 |
| Red blood cell | 54 | 1.0 (0.0-2.0) | 1.3 (1.0-1.8) | 47 | 2.0 (1.0-3.0) | 2.5 (1.9-3.2) | 0.53 (0.36-0.78) | .001 |
| Cumulative allogeneic blood components within 7 d after CPB | ||||||||
| RBC + platelet + FP (including IMP) | 54 | 7.0 (5.0-11.0) | 8.5 (7.1-10.1) | 47 | 13.0 (8.0-19.0) | 14.2 (11.9-16.9) | 0.60 (0.47-0.76) | <.001 |
| RBC + platelet + FP (excluding IMP) | 54 | 7.0 (5.0-11.0) | 8.4 (6.9-10.2) | 47 | 10.0 (5.0-15.0) | 10.3 (8.4-12.6) | 0.81 (0.62-1.07) | .15 |
| Individual allogeneic blood components within 7 d after CPB | ||||||||
| FP (including IMP) | 54 | 0 | 0.3 (0.2-0.4) | 47 | 4.0 (2.0-4.0) | 4.2 (3.4-5.1) | 0.06 (0.03-0.11) | <.001 |
| Platelet | 54 | 4.0 (4.0-8.0) | 6.1 (4.9-7.5) | 47 | 8.0 (4.0-12.0) | 6.8 (5.5-8.5) | 0.89 (0.66-1.21) | .50 |
| Red blood cell | 54 | 2.0 (1.0-3.0) | 2.1 (1.7-2.7) | 47 | 3.0 (1.0-4.0) | 3.2 (2.6-4.0) | 0.67 (0.48-0.92) | .01 |
| Cumulative allogeneic blood components within 24 h after start of intervention | ||||||||
| RBC + platelet + FP (including IMP) | 54 | 2.0 (0.0-5.0) | 4.1 (3.1-5.6) | 47 | 6.0 (4.0-14.0) | 9.9 (7.3-3.4) | 0.42 (0.27-0.64) | <.001 |
| RBC + platelet + FP (excluding IMP) | 54 | 2.0 (0.0-5.0) | 4.1 (2.8-6.0) | 47 | 2.0 (1.0-10.0) | 5.8 (3.9-8.8) | 0.70 (0.40-1.22) | .20 |
| Individual allogeneic blood components within 24 h after start of intervention | ||||||||
| FP (including IMP) | 54 | 0 | 0.3 (0.2-0.5) | 47 | 4.0 (3.0-4.0) | 4.4 (3.6-5.3) | 0.06 (0.03-0.11) | <.001 |
| Platelet | 54 | 0.0 (0.0-4.0) | 3.0 (1.8-4.9) | 47 | 0.0 (0.0-8.0) | 3.6 (2.1-6.1) | 0.83 (0.40-1.72) | .60 |
| Red blood cell | 54 | 0.0 (0.0-1.0) | 0.9 (0.6-1.3) | 47 | 2.0 (0.0-3.0) | 2.0 (1.4-2.7) | 0.46 (0.28-0.76) | .003 |
Abbreviations: CPB, cardiopulmonary bypass; FP, frozen plasma; IMP, investigational medicinal product; IQR, interquartile range; LS, least-squares; PCC, prothrombin complex concentrate; RBC, red blood cell.
a
Units of allogenic blood components counted as follows: each RBC unit, 1 U; each 250 mL plasma unit, 1 U; and each platelet dose, 4 U.
b
If patients required repeated CPB, the end time of the last procedure was used for calculations.