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. 2021 Mar 16:M20-7569. doi: 10.7326/M20-7569

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This article is made available via the PMC Open Access Subset for unrestricted re-use for research, analyses, and text and data mining through PubMed Central. Acknowledgement of the original source shall include a notice similar to the following: "© 2020 American College of Physicians. Some rights reserved. This work permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited." These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure. Evidence description. Evidence search and assessment done by the Portland VA Research Foundation (3, 4). Updated search for evidence updated through 15 December 2020. * Observational studies include studies estimating seroprevalence among a given population that includes a small subpopulation known to have SARS-CoV-2 and cross-sectional or cohort studies characterizing the antibody response among adults with SARS-CoV-2 infection. Immunoassay validation studies include those validating the diagnostic performance of 1 or more immunoassays (3, 4). — Evidence search and assessment done by the Portland VA Research Foundation (3, 4). Updated search for evidence updated through 15 December 2020.

* Observational studies include studies estimating seroprevalence among a given population that includes a small subpopulation known to have SARS-CoV-2 and cross-sectional or cohort studies characterizing the antibody response among adults with SARS-CoV-2 infection. Immunoassay validation studies include those validating the diagnostic performance of 1 or more immunoassays (3, 4).