Table 3. Incidence of Treatment-Emergent Adverse Events Occurring in 20% or More of Patients.
| Preferred term | No. (%) | |||||
|---|---|---|---|---|---|---|
| Tislelizumab + paclitaxel + carboplatin (n = 120) | Tislelizumab + nab-paclitaxel + carboplatin (n = 118) | Paclitaxel + carboplatin (n = 117) | ||||
| All grades | Grade ≥3 | All grades | Grade ≥3 | All grades | Grade ≥3 | |
| Anemia | 106 (88.3) | 9 (7.5) | 110 (93.2) | 27 (22.9) | 94 (80.3) | 14 (12.0) |
| Alopecia | 77 (64.2) | 0 | 82 (69.5) | 0 | 72 (61.5) | 0 |
| Decreased neutrophil levels | 76 (63.3) | 62 (51.7) | 72 (61.0) | 54 (45.8) | 68 (58.1) | 53 (45.3) |
| Decreased white blood cell count | 64 (53.3) | 27 (22.5) | 68 (57.6) | 32 (27.1) | 62 (53.0) | 28 (23.9) |
| Leukopenia | 57 (47.5) | 19 (15.8) | 66 (55.9) | 30 (25.4) | 56 (47.9) | 21 (17.9) |
| Decreased appetite | 52 (43.3) | 1 (0.8) | 52 (44.1) | 1 (0.8) | 36 (30.8) | 1 (0.9) |
| Neutropenia | 51 (42.5) | 40 (33.3) | 50 (42.4) | 32 (27.1) | 55 (47.0) | 47 (40.2) |
| Increased ALT levels | 50 (41.7) | 2 (1.7) | 41 (34.7) | 2 (1.7) | 27 (23.1) | 0 |
| Increased AST | 43 (35.8) | 0 | 40 (33.9) | 1 (0.8) | 14 (12.0) | 0 |
| Decreased platelet cell count | 41 (34.2) | 5 (4.2) | 52 (44.1) | 16 (13.6) | 28 (23.9) | 2 (1.7) |
| Pain in extremity | 40 (33.3) | 3 (2.5) | 17 (14.4) | 0 | 27 (23.1) | 0 |
| Nausea | 36 (30.0) | 0 | 51 (43.2) | 0 | 35 (29.9) | 1 (0.9) |
| Constipation | 36 (30.0) | 0 | 33 (28.0) | 0 | 27 (23.1) | 0 |
| Thrombocytopenia | 33 (27.5) | 7 (5.8) | 47 (39.8) | 15 (12.7) | 32 (27.4) | 7 (6.0) |
| Asthenia | 29 (24.2) | 0 | 21 (17.8) | 0 | 24 (20.5) | 1 (0.9) |
| Vomiting | 28 (23.3) | 1 (0.8) | 27 (22.9) | 0 | 20 (17.1) | 2 (1.7) |
| Increased blood bilirubin levels | 27 (22.5) | 0 | 15 (12.7) | 0 | 15 (12.8) | 0 |
| Hypoesthesia | 27 (22.5) | 0 | 12 (10.2) | 0 | 19 (16.2) | 0 |
| Hypoalbuminemia | 27 (22.5) | 1 (0.8) | 21 (17.8) | 0 | 19 (16.2) | 0 |
| Rash | 25 (20.8) | 4 (3.3) | 26 (22.0) | 2 (1.7) | 4 (3.4) | 0 |
| Arthralgia | 25 (20.8) | 0 | 21 (17.8) | 0 | 19 (16.2) | 0 |
| Pyrexia | 24 (20.0) | 0 | 24 (20.3) | 1 (0.8) | 18 (15.4) | 0 |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; nab, nanoparticle albumin-bound.