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. 2021 Mar 19;12:625084. doi: 10.3389/fphar.2021.625084

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Copyright © 2021 Bao, Zheng, Ye, Huang, Zhou, Yao, Lin, Zhang, Kou and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ROS-p38 axis was involved in the enhanced anticancer efficacy of AE@NPs (A) Representative images of cells stained with DCFH-DA to detect intracellular ROS generation (magnification: ×200). Quantification of GSH/GSSG ratio in (B) PANC-1 and (C) Patu-8988T cells after various treatments (D) PANC-1 and (E) Patu8988T were treated with various treatments for 18 h. The protein levels of p-p38, p38 were measured by western blot, with β-actin as an internal control. The data were shown as mean ± SD. *p < 0.05 **p < 0.01, compared to the control group.