Table 1.

Grading of Recommendations, Assessment, Development and Evaluation system for rating quality of evidence

Quality of evidence	Definition
High quality	Further research is very unlikely to change confidence in the estimate of effect
Moderate quality	Further research is likely to have an important impact on confidence in the estimate of effect and may change the estimate
Low quality	Further research is very likely to have an important impact on confidence in the estimate of effect and is likely to change the estimate
Very low quality	Any estimate of effect is very uncertain