Figure 1.

Artistic interpretation of a confocal 3D reconstruction of a pancreatic islet highlighting the complexity of this micro-organ with intricate interactions among the endocrine cells, blood vessels, and nerves. Depicted in yellow are beta cells, in cyan alpha cells, in magenta delta cells, in red blood vessels, and in white nerves. The depiction is based on a prototypical rodent islet with a core of beta cells (accounting for up to 90% of the islet endocrine cells) and with alpha and delta cells in the mantle.