Figure 3.

Sensitivity analyses assessing the effect of variation in key model parameters on the number of PALYs, compared with the base-case analysis. The tornado diagram demonstrates the model is most sensitive to variations in the increased risk of early labor force withdrawal associated with kidney disease. Black bars denote the lower-bound estimate has been used, whereas the white bars indicate use of the upper-bound estimate of the parameter. Bars represent the difference in the number of PALYs compared with the base case. In the base-case analysis, the total PALYs among working age Australians in 2020–2029 was 89,783,023 (Table 2). Note that due to a lack of available data for the intervals, the HR of early labor-force withdrawal due to CKD (as reported by Klarenbach et al.¹⁰) was assumed to vary by 30%.