TABLE 5.

Top pathways enriched in pleiotropic regions for carcass quality, sensory meat quality, and visual meat quality traits from the DAVID functional annotation module analysis.

Annotation Cluster 1	Enrichment Score: 28.96
Category	Term	Count	%	P-value	FDR
GOTERM_CC_DIRECT	GO:0005882∼intermediate filament	29	10.10	1.35E-36	3.08E-34
GOTERM_CC_DIRECT	GO:0045095∼keratin filament	22	7.67	2.53E-24	2.90E-22
INTERPRO	IPR001664:Intermediate filament protein	41	14.29	5.19E-54	2.41E-51
INTERPRO	IPR018039:Intermediate filament protein, conserved site	33	11.50	7.59E-44	1.76E-41
INTERPRO	IPR002957:Keratin, type I	25	8.71	1.78E-39	2.76E-37
INTERPRO	IPR003054:Type II keratin	15	5.23	6.33E-20	7.36E-18
Annotation Cluster 2	Enrichment Score: 1.97
Category	Term	Count	%	P-value	FDR
GOTERM_BP_DIRECT	GO:0043066∼negative regulation of apoptotic process	8	2.79	0.0815398	1
GOTERM_BP_DIRECT	GO:0008284∼positive regulation of cell proliferation	6	2.09	0.3570181	1
GOTERM_BP_DIRECT	GO:0019221∼cytokine-mediated signaling pathway	3	1.05	0.5191902	1
INTERPRO	IPR000980:SH2 domain	7	2.44	0.0070389	0.142308
INTERPRO	IPR008967:p53-like transcription factor, DNA-binding	6	2.09	4.79E-04	0.018573
INTERPRO	IPR011992:EF-hand-like domain	6	2.09	0.335048	0.978947
INTERPRO	IPR013801:STAT transcription factor, DNA-binding	4	1.39	7.32E-05	0.004865
INTERPRO	IPR001217:STAT transcription factor, core	4	1.39	1.27E-04	0.005355
INTERPRO	IPR013799:STAT transcription factor, protein interaction	4	1.39	1.27E-04	0.005355
INTERPRO	IPR013800:STAT transcription factor, all-alpha	4	1.39	1.27E-04	0.005355
INTERPRO	IPR015988:STAT transcription factor, coiled coil	4	1.39	1.27E-04	0.005355
Annotation Cluster 3	Enrichment Score: 1.65
Category	Term	Count	%	P-value	FDR
GOTERM_BP_DIRECT	GO:0043651∼linoleic acid metabolic process	3	1.05	0.0033093	0.64134
GOTERM_BP_DIRECT	GO:0019372∼lipoxygenase pathway	3	1.05	0.0045868	0.64134
GOTERM_BP_DIRECT	GO:0019369∼arachidonic acid metabolic process	3	1.05	0.0160454	1
GOTERM_MF_DIRECT	GO:0005506∼iron ion binding	3	1.05	0.6926433	1
INTERPRO	IPR020834:Lipoxygenase, conserved site	3	1.05	0.0035124	0.116661
INTERPRO	IPR020833:Lipoxygenase, iron binding site	3	1.05	0.0048667	0.125722
INTERPRO	IPR000907:Lipoxygenase	3	1.05	0.0048667	0.125722
Annotation Cluster 4	Enrichment Score: 1.42
Category	Term	Count	%	P-value	FDR
GOTERM_BP_DIRECT	GO:0007156∼homophilic cell adhesion via plasma membrane adhesion molecules	5	1.74	0.0602773	1
GOTERM_MF_DIRECT	GO:0005509∼calcium ion binding	10	3.48	0.6254933	1
INTERPRO	IPR013164:Cadherin, N-terminal	5	1.74	6.69E-04	0.023919
INTERPRO	IPR020894:Cadherin conserved site	5	1.74	0.0229436	0.426751
INTERPRO	IPR002126:Cadherin	5	1.74	0.0287627	0.477666
Annotation Cluster 5	Enrichment Score: 1.26
Category	Term	Count	%	P-value	FDR
GOTERM_BP_DIRECT	GO:0015031∼protein transport	8	2.79	0.0218376	1
UP_KEYWORDS	Protein transport	9	3.14	0.0682724	0.989189
Annotation Cluster 6	Enrichment Score: 1.19
Category	Term	Count	%	P-value	FDR
GOTERM_MF_DIRECT	GO:0008270∼zinc ion binding	13	4.53	0.8806512	1
GOTERM_MF_DIRECT	GO:0003707∼steroid hormone receptor activity	4	1.39	0.0515058	1
INTERPRO	IPR001723:Steroid hormone receptor	5	1.74	0.005717	0.13292
Annotation Cluster 7	Enrichment Score: 1.16
Category	Term	Count	%	P-value	FDR
UP_KEYWORDS	Protein biosynthesis	5	1.74	0.0726088	0.989189
UP_KEYWORDS	Initiation factor	3	1.05	0.1521805	0.989189
GOTERM_MF_DIRECT	GO:0003743∼translation initiation factor activity	3	1.05	0.2050301	1
Annotation Cluster 8	Enrichment Score: 1.10
Category	Term	Count	%	P-value	FDR
GOTERM_BP_DIRECT	GO:0006351∼transcription, DNA-templated	14	4.88	0.129625	1
GOTERM_BP_DIRECT	GO:0045893∼positive regulation of transcription, DNA-templated	7	2.44	0.1925483	1
GOTERM_MF_DIRECT	GO:0003677∼DNA binding	16	5.57	0.1211263	1
GOTERM_MF_DIRECT	GO:0003700∼transcription factor activity, sequence-specific DNA binding	8	2.79	0.6537571	1

Statistics associated with GO terms include significance of enrichment or EASE score (P-value) and false discovery rate (FDR).