Figure 5.

(A) Interaction model between nasal SPT (serine palmitoyl-CoA transferase) and ORMDL3 gene expression (x-axes) and 17q21 genotypes in relation to plasma phosphosphingolipid levels. (B) Association between nasal SPT and ORMDL3 gene expression (x-axes) and phosphosphingolipid levels stratified by 17q21 genotypes. Each point represents the β-estimate of the association, the dotted vertical lines represent the confidence intervals, and each color indicates the genotype stratum expressed as the number of risk alleles. *P ≤ 0.05.