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. 2021 Feb 1;118(6):e2002787118. doi: 10.1073/pnas.2002787118

Fig. 4.

Fig. 4.

Tbx21−/− Th2 but not WT Th2 cells protect mice against type 1 diabetes development. (A) Percentage of diabetes development in RIP-GP recipients of Tbx21−/− Th2 and WT Th2 cells and control RIP-GP mice without cell transfer until day 12 post LCMV infection. P values were calculated by log-rank test. (B) Blood glucose levels in RIP-GP recipients of Tbx21−/− Th2 and WT Th2 cells and control RIP-GP mice without cell transfer until day 12 postinfection. P values are from day 12 postinfection. (C) Frequencies of endogenous GP33-tetramer+ CD8+ T cells in RIP-GP recipients of Tbx21−/− Th2 and WT Th2 cells and nontransferred control RIP-GP mice in the blood at day 8 postinfection. All experiments were performed at least twice, and each experimental group included n ≥ 3. Data are pooled and expressed as mean ± SEM. Asterisks indicate statistically significant differences as analyzed by one-way ANOVA with Bonferroni’s post test (*P < 0.05, **P < 0.01).