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. 2021 Apr 1;9:59. doi: 10.1186/s40478-021-01167-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — B7-H3 is mainly expressed by neoplastic cells, pericytes and myeloid cells. a CD276 gene expression profiles in different cell types using data generated by Darmanis et al. (2017). b, d, f, and h Representative images of B7-H3 (red) co-labeled with (b) SOX2 (d) Nestin (f) PDGFRβ and (h) Iba1 (green) in non-cancerous (NC) brain (N = 5) versus GBM (N = 6) tissues. DAPI (blue) was used to counterstain nuclei. Major scale bar = 50 µm and scale bar for enlarged images = 10 µm. c, e, g and i Percentage of B7-H3 positive cells expressing SOX2, Nestin, PDGFRβ and Iba1 in NC brain (N = 5) versus GBM (N = 6) tissues. Graphs are mean ± SD *p < 0.05 **p < 0.01 and ***p < 0.001 (t-test)