Skip to main content
. 2021 Feb 3;118(6):e2013776118. doi: 10.1073/pnas.2013776118

Fig. 3.

Fig. 3.

Endometrial macrophage depletion impacts lesion size. (A) Schematic demonstrating timing of doxycycline administration to iCsf1r-KO donor mice. Donor endometrium was generated in iCsf1r-KO mice, with doxycycline administered to donor mice from days 15 to 19 to deplete endometrial macrophages prior to recovery of endometrium and i.p. transfer to wild-type recipients. Lesions were recovered 2 wk after tissue injection. (B) Quantification of F4/80hi, Ly6Clo macrophages and Ly6Chi, F4/80lo monocytes in donor endometrium from wild-type and iCsf1r-KO mice. (C) Number of lesions recovered from wild-type recipient mice receiving either wild-type (n = 10) or iCsf1r-KO endometrium (n = 9) (from two independent experiments). (D) Area of lesions recovered from mice receiving either wild-type or iCsf1r-KO endometrium. Data are presented as mean ± SEM or 95% confidence intervals (C). Statistical significance was determined using a Student’s t test. *P < 0.05.