Fig. 3.
Manhattan plots of exome wide associations in the four main models excluding the APOE region. The age-adjusted logistic regression has no suggestive association (dashed line, p < 1 × 10−5). The main causal variant on TREM2 is exome-wide significant (solid line, p < 5 × 10−7) in the other three models. Among suggestive associations, (i) known AD associations are in red and (ii) novel associations which replicate (p < 0.05) in an independent dataset are in blue (cf Table 3). Colored dots were bootstrapped in the AD-age score model (see the “Methods” section). The minimum p value from the adjustment models for each main model is displayed as in [7]