Table 1.
Detailed demographics for discovery and replication sample. Details per cohort included in the discovery and replication can be found respectively in Tables S1 and S2. HC healthy controls, AD Alzheimer’s disease
| Sample |
N (% females) |
Age μ (σ) |
ε3/ε3 (%) |
ε3/ε4 (%) |
ε4/ε4 (%) |
ε2/ε3 (%) |
ε2/ε4 (%) |
ε2/ε2 (%) |
|---|---|---|---|---|---|---|---|---|
| Discovery – (WES + WGS) | ||||||||
| Controls | 5075 (59.0) | 85.2 (5.4) | 66.13 | 13.93 | 0.51 | 17.12 | 1.52 | 0.79 |
| AD cases | 6052 (57.8) | 76.3 (8.2) | 47.54 | 39.29 | 4.23 | 6.08 | 2.46 | 0.4 |
| Replication – (imputed SNP arrays) | ||||||||
| Controls | 10,539 (59.4) | 76.7 (8.5) | 60.98 | 22.01 | 2.07 | 12.11 | 2.18 | 0.65 |
| AD cases | 11,092 (60.5) | 73.3 (9.3) | 32.83 | 44.37 | 16.21 | 3.69 | 2.79 | 0.1 |