Table 1.
Concentrations of plasma biomarkers at − 10 d relative to parturition in cows classified according to normal body condition score (BCS) (≤ 3.25, NormBCS; n = 30) or high BCS (≥ 3.75, HighBCS; n = 19) at 4 weeks prior to parturition
| Itema | Cow BCS | SEM | ||
|---|---|---|---|---|
| HighBCS | NormBCS | HighBCS | NormBCS | |
| Energy metabolism | ||||
| BHBA, mmol/L | 0.44 | 0.46 | 0.03 | 0.02 |
| Creatinine, μmol/L | 96.2 | 95.4 | 1.98 | 1.40 |
| Glucose, mmol/L | 4.59* | 4.39 | 0.07 | 0.05 |
| NEFA, mmol/L | 0.30* | 0.19 | 0.03 | 0.02 |
| Urea, mmol/L | 5.40* | 6.16 | 0.19 | 0.26 |
| Liver function | ||||
| AST/GOT, U/L | 68.7 | 75.3 | 3.37 | 2.72 |
| Cholesterol, mmol/L | 2.54* | 2.86 | 0.13 | 0.09 |
| GGT, U/L | 18.8 | 20.5 | 1.43 | 1.01 |
| Total bilirubin, μmol/L | 1.12 | 0.98 | 0.26 | 0.16 |
| Inflammation | ||||
| Albumin, g/L | 36.2 | 36.3 | 0.36 | 0.26 |
| Ceruloplasmin, μmol/L | 2.54* | 2.30 | 0.09 | 0.07 |
| Haptoglobin, g/L | 0.26 | 0.26 | 0.03 | 0.02 |
| Myeloperoxidase, U/L | 478 | 453 | 30.8 | 20.9 |
| Oxidative stress | ||||
| Paraoxonase, U/mL | 86.9 | 87.7 | 4.09 | 2.89 |
| FRAP, μmol/L | 104 | 111 | 3.37 | 2.60 |
| NOx, μmol/L | 31.5* | 29.9 | 0.64 | 0.47 |
| Nitrites, μmol/L | 7.51 | 7.24 | 0.67 | 0.47 |
| Nitrates, μmol/L | 23.3 | 22.4 | 0.82 | 0.58 |
| ROM, mg H2O2/100 mL | 13.3 | 12.5 | 0.37 | 0.27 |
| Retinol, μg/100 mL | 27.9 | 31.5 | 1.87 | 1.35 |
| Tocopherol, μg/mL | 3.49 | 3.81 | 0.34 | 0.24 |
aAST aspartate aminotransferase, BHBA betahydroxybutyrate, GGT γ-glutamyl transpeptidase, FRAP ferric reducing ability of plasma, NEFA nonesterified fatty acids, NOx nitric oxide, ROM reactive oxygen metabolites
*Means differ P ≤ 0.05 between groups