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. 2021 Apr 1;21:276. doi: 10.1186/s12884-021-03752-2

Table 2.

Psychological interventions vs care-as-usual control groups for preventing distress among pregnant women: effect sizesa

N comp d 95% CI p-value I2 NNT
All studies 14 0.52 0.29 ~ 0.74 76.14* 3.50
2 outliers removed 12 0.47 0.31 ~ 0.62 26.56 ns 3.85
Lowest ES excludedb 12 0.50 0.36 ~ 0.64 14.9 ns 3.62
Highest ES excludedb 12 0.43 0.25 ~ 0.61 41.54 ns 4.20
Depression onlyb 10 0.50 0.32 ~ 0.67 26.99 ns 3.62
Anxiety onlyb 5 0.30 < 0.01 ~ 0.59 43.03 ns 5.95
Stress onlyb 5 0.52 0.28 ~ 0.75 00.00 ns 3.50
Timing interventionb 0.63
 • Prenatal 9 0.52 0.36 ~ 0.68 07.32 ns 3.50
 • Mixed 3 0.37 0.16 ~ 0.58 60.95 ns 4.85
Intervention typeb 0.54
 • Psychoeducation 3 0.34 0.03 ~ 0.65 22.77 ns 5.26
 • CBT 3 0.43 0.24 ~ 0.62 66.23 ns 4.20
 • Mindfulness 3 0.32 −.14 ~ 0.78 0.00 ns 5.56
 • Other 3 0.62 0.39 ~ 0.84 43.81 ns 2.96
Delivery modeb 0.54
 • Group 10 0.45 0.32 ~ 0.58 34.52 ns 4.00
 • Individual 2 0.61 0.13 ~ 1.10 00.00 ns 2.99
Inclusion of partnerb < 0.01
 • No 8 0.59 0.43 ~ 0.75 0.00 ns 3.09
 • Yes 4 0.25 0.04 ~ 0.45 0.00 ns 7.14
Risk of biasb 0.40
 • High 5 0.55 0.32 ~ 0.78 38.08 ns 3.31
 • Low 2 0.56 0.32 ~ 0.81 00.00 ns 3.25
 • Medium 5 0.35 0.16 ~ 0.54 26.78 ns 5.10
Timing post-testb 0.93
 • Pregnancy 5 0.48 0.30 ~ 0.67 0.00 ns 3.76
 • 0–6 m pp 7 0.45 0.27 ~ 0.62 51.54 ns 4.00

a random effect models; b analysis did not include four outliers (Khorsandi; Haga); N comp number of comparisons; ns: not statistically significant; NNT Numbers Needed to Treat