Table 4.
RI | NRM | LFS | OS | GRFS | aGVHD grade II–IV | aGVHD grade III–IV | cGVHD | ext. cGVHD | |
---|---|---|---|---|---|---|---|---|---|
MSD | 31.6% [29.2–34%] | 13% [11.4–14.7%] | 55.4% [52.8–57.9%] | 67.4% [64.8–69.8%] | 39% [36.4–41.5%] | 28.9% [26.8–31.1%] | 10.5% [9.1–12%] | 38.8% [36.3–41.3%] | 19.5% [17.5–21.7%] |
Haplo | 26% [21.5–30.8%] | 22.9% [18.8–27.3%] | 51% [45.7–56.2%] | 58.8% [53.3–63.9%] | 40.6% [35.4–45.7%] | 36.3% [31.5–41.1%] | 15.2% [11.9–19%] | 32% [27.1–37.1%] | 11.9% [8.6–15.8%] |
p | 0.017 | 0.001 | 0.07 | 0.001 | 0.74 | 0.002 | 0.005 | 0.009 | 0.001 |
RI, relapse incidence; NRM, non-relapse mortality; LFS, leukemia-free survival; OS, overall survival; GVHD, graft versus host disease; GRFS, GVHD-free/relapse-free survival; KPS, Karnofsky performance status; ATG, anti-thymocyte globulin; PTCy, post-transplant cyclophosphamide; RIC, reduced intensity conditioning; MAC, myeloablative conditioning; PB, peripheral blood; BM, bone marrow