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A case of reactive plasmacytoid dendritic cell proliferation positive for CD56 by immunohistochemistry. (A) A skin biopsy shows small clusters of plasmacytoid dendritic cells (PDC), some with plasmacytoid morphology in a self-limited skin lesion, likely caused by an insect bite. The insert shows the low-power view of the skin biopsy. (B) Double staining for CD123/TCF4 highlights scattered and loosely clustered PDC. (C) CD56 immunostaining shows that many PDC are positive.
