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. 2021 Feb 4;106(4):1008–1021. doi: 10.3324/haematol.2020.264432

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Copyright© 2021 Ferrata Storti Foundation

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Figure 6. — All-trans retinoic acid (ATRA)/bexarotene in different leukemia cell lines and in human acute myeloid leukemia (AML) ex vivo. (A and B) Colony forming units (CFU) in methylcellulose per 2,000 Dnmt3a R878H/FLT3-ITD and Tet2-KO/FLT3-ITD leukemia cells treated as indicated for 7 days in duplicate. (C) Zip synergy score of ATRA and bexarotene interactions calculated by SynergyFinder.24 (D and E) Cell viability of primary human AML leukemia samples treated for 96 hours ex vivo with ATRA and bexarotene at indicated concentrations assessed in duplicate by CellTiter-Glo (CTG). Dx: sample acquired at initial diagnosis; R: sample acquired at relapse. *P<0.05, **P<0.01, t-test relative to control.