Fig. 1.

Detection of SARS-CoV-2 N-antigen in the serum of COVID-19 patients associates with inflammation.

(A) Bar histogram showing SARS-CoV-2 N-antigen concentrations (pg/mL) in serum of COVID-19 and healthy subjects (HS). ***P < 0.001 by Mann-Whitney U test. (B) SARS-CoV-2 N-antigen concentrations in COVID-19 patients from diagnosis (T0), to clinical improvement (T1) and until recovery (T2). *P < 0.05 T0 versus T1; ^§P < 0.01 T0 versus T2 by one-way ANOVA test, multiple comparison corrected for Bonferroni's test. (C) Bar histogram showing SARS-CoV-2 N-antigen concentration in COVID-19 patients stratified on the basis of serum CRP levels, as mild (≤ 5 mg/L), moderate (6–20 mg/L) and severe (21–80 mg/L) disease. ****P < 0.0001 by Mann-Whitney U test. Data are shown as mean ± S.E.M..