Skip to main content
. 2021 Feb 1;118(6):e2001679118. doi: 10.1073/pnas.2001679118

Fig. 3.

Fig. 3.

TWEAK attenuates synaptic transmission through presynaptic mechanisms. (A) Paired-pulse recordings showing the ratio of the second to the first fEPSP (S2/S1) using 25-, 50-, and 100-ms ISIs at baseline and after control protein (1 μg/mL) or Fc-TWEAK (0.5 μg/mL) ex vivo wash-in in HC slices from 6- to 8-wk-old male and female WT mice. n = 6 to 10 slices/group. Data are expressed as the mean ± SEM. One-way ANOVA, Tukey’s multiple comparisons test. *P ≤ 0.05, compared to control protein-treated group. (B) Representative traces of paired-pulse recordings showing the first (S1) and the second (S2) fEPSPs with 50-ms ISI after control protein or Fc-TWEAK wash-in. (C) Representative mEPSC recording traces in baseline conditions and following TWEAK wash-in. (D) Quantification of mEPSC recordings. Data points from individual neurons, frequencies, and amplitudes normalized to baseline. Paired t test. *P ≤ 0.05.