FIGURE 3.

FynT upregulation in AD and LBD correlates with cognitive impairment and neuropathological features. (A) FynT and FynB expression were determined by real‐time RT‐PCR in BA9 and BA21, derived from CTRL (n = 13–15, red), AD (n = 11–12, blue), DLB (n = 25–31, amber), and PDD (n = 14–21, green). Data were Log₂ transformed and depicted as box plots, with the horizontal intersecting lines and borders indicating median and interquartile range for each group, while whiskers show the highest and lowest values not considered outliers. (B) Scatter plots of Log₂‐transforemd FynT expression against pre‐death cognition (MMSE) scores in BA9 (left) and BA21 (right) in the combined dementia cohort. Solid lines indicated linear regressed best‐fit curves while dashed lines indicated their respective 95% confidence intervals, with insets showing Pearson's correlation coefficients (r) and their respective p values. (C) Table of correlation coefficients for FynT or FynB expression with neuropathologic scores, Braak stage and biochemical measures of pS396Tau and soluble Aβ42 (in pg/mg protein) were analyzed using samples derived from CTRL, AD, and LBD. **p < 0.01, ***p < 0.001, significant differences compared to CTRL by one‐way ANOVA with post hoc Bonferroni's tests. ^¶Pearson's (r) and ^§Spearman's (ρ) correlation coefficients with p < 0.05