FIGURE 5.

Selective upregulation of FynT in aged transgenic P301S tau mice correlates with tauopathy and neuroinflammation. (A) Determination of phosphorylated tau (pS202/T205 tau), aggregated tau and total tau protein by HTRF in the brain homogenates of P301S Tau transgenic mice and wild‐type littermate controls at age <6 mo (before onset of pathology, labels in small letters: p301 s, wt) and ≥6 mo (with disease progression, labels in capital letters: P301S, WT). RT‐PCR derived values for relative expressions of (B) FynT, FynB (together with FynT to FynB ratios) as well as (C) GFAP and CD11b in the samples as described above. Horizontal lines on the dot plots in each group indicate median and interquartile range. (D) Table of correlation coefficients for FynT, FynB, FynT:FynB with phosphorylated tau, aggregated tau, and neuroinflammation markers. *p < 0.05, **p < 0.01, ***p < 0.001, significant pairwise differences by two‐way ANOVA with post hoc Bonferroni's tests (Significance of the Genotype, Age, and Interaction factors are given in the respective insets of each graph). ^¶Pearson's (r) correlation coefficients with p < 0.05