TABLE 2.
Top five* GO Terms under BP and CC categories for FynT positively and negatively correlated genes derived from CTRL, AD, and LBD transcriptome profiling data
| GO term ID (categories) | Description (FynT positively correlated genes) | Count a | Fold enrichment b | Benjamini c |
|---|---|---|---|---|
| GO:0005913 (CC) | Cell–cell adherens junction | 34 | 4.07 | 2.64E‐09 |
| GO:0005925 (CC) | focal adhesion | 37 | 3.66 | 4.69E‐09 |
| GO:0030027 (CC) | lamellipodium | 18 | 4.35 | 5.62E‐05 |
| GO:0030175 (CC) | filopodium | 12 | 6.54 | 9.64E‐05 |
| GO:0001726 (CC) | ruffle | 13 | 5.59 | 1.53E‐04 |
| GO:0098609 (BP)* | Cell–cell adhesion | 24 | 3.23 | 4.00E‐03 |
| GO:0016569 (BP)* | covalent chromatin modification | 14 | 4.51 | 1.52E‐02 |
| GO term ID (categories) | Description (FynT negatively correlated genes) | Count a | Fold enrichment b | Benjamini c |
|---|---|---|---|---|
| GO:0043209 (CC) | myelin sheath | 54 | 4.75 | 3.64E‐20 |
| GO:0030054 (CC) | cell junction | 91 | 2.65 | 1.62E‐15 |
| GO:0014069 (CC) | postsynaptic density | 50 | 3.64 | 2.66E‐13 |
| GO:0008021 (CC) | synaptic vesicle | 33 | 4.80 | 5.41E‐12 |
| GO:0045211 (CC) | postsynaptic membrane | 49 | 3.11 | 2.28E‐10 |
| GO:0016192 (BP) | vesicle‐mediated transport | 40 | 3.41 | 2.46E‐08 |
| GO:0034220 (BP) | ion transmembrane transport | 48 | 2.96 | 2.57E‐08 |
| GO:0006886 (BP) | intracellular protein transport | 52 | 2.85 | 4.34E‐08 |
| GO:0000165 (BP) | MAPK cascade | 54 | 2.67 | 6.03E‐08 |
| GO:0016241 (BP) | regulation of macroautophagy | 20 | 5.88 | 1.06E‐07 |
Gene ontology (GO) category: biological process (BP) and cellular component (CC).
a
Count represents the total number of genes correlated with FynT in the respective GO term.
b
Fold enrichment is used to measure the magnitude of enrichment.
c
p values adjusted for multiple testing using FDR < 0.05.
*
For FynT positively correlated genes, only two BP terms were significant at FDR < 0.05.