Table 4.
Top 12 Gene Ontology functional annotations associated with the expression of MKI67 (sorted by fold enrichment).
| GO biological process | Fold enrichment | FDR |
|---|---|---|
| Enrichment in tumors showing MKI67 higher expression | ||
| Condensin complex (GO:796) | 50.2 | <0.0001 |
| Replication fork protection complex (GO:31298) | 42.1 | <0.0001 |
| DNA strand elongation involved in cell cycle DNA replication (GO:1902296) | 40.1 | <0.0001 |
| Ndc80 complex (GO:31262) | 40.1 | <0.0001 |
| Pre‐replicative complex assembly (GO:36388) | 35.1 | <0.0001 |
| Leading strand elongation (GO:6272) | 35.1 | <0.0001 |
| Condensed nuclear chromosome kinetochore (GO:778) | 31.6 | <0.0001 |
| MCM complex (GO:42555) | 28.1 | 0.0001 |
| Mitotic centrosome separation (GO:7100) | 28.1 | 0.0001 |
| Mitotic chromosome condensation (GO:7076) | 27.5 | <0.0001 |
| Kinetochore microtubule (GO:5828) | 25.5 | 0.0001 |
| Aster (GO:5818) | 25.5 | 0.0001 |
| Enrichment in tumors showing MKI67 lower expression | ||
| Regulation of inclusion body assembly (GO:90083) | 12.3 | 0.03 |
| Beta‐amyloid binding (GO:1540) | 10.5 | 0.005 |
| Neurotrophin TRK receptor signaling pathway (GO:48011) | 7.9 | 0.04 |
| Import into cell (GO:98657) | 6.6 | 0.01 |
| Sodium ion transmembrane transport (GO:35725) | 4.7 | 0.03 |
| Synaptic vesicle (GO:8021) | 4.1 | 0.007 |
| Postsynaptic specialization (GO:99572) | 3.7 | 0.001 |
| Axon part (GO:33267) | 3.7 | <0.0001 |
| Excitatory synapse (GO:60076) | 3.7 | 0.001 |
| Myelin sheath (GO:43209) | 3.4 | 0.01 |
| Dendrite (GO:30425) | 2.6 | 0.001 |
| Trans‐synaptic signaling (GO:99537) | 2.5 | 0.001 |
FDR = false discovery rate; GO = gene ontology.