Table 1.
Clinical and neuropathological data of subjects in the stereological study.
| Case | Brain bank ID | Group | Age (y) | Sex | PMT (h) | APOE genotype | Atrophy | Duration of dementia (y) | NFT score | Neuritic plaque score (CERAD) (36) | Capillary CAA (54) | Cause of death |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | H122 | CTRL | 72 | F | 9 | E3/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Emphysema |
| 2 | H109 | CTRL | 81 | M | 7 | E3/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Coronary atherosclerosis |
| 3 | H110 | CTRL | 83 | F | 14 | E2/E2 | n.d. | 0 | n.d. | n.d. | Neg. | Ruptured aortic aneurysm |
| 4 | H137 | CTRL | 77 | F | 12 | E3/E4 | n.d. | 0 | n.d. | n.d. | Neg. | Coronary atherosclerosis |
| 5 | H131 | CTRL | 73 | F | 13 | E3/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Ischemic heart disease |
| 6 | H150 | CTRL | 78 | M | 12 | E3/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Ruptured myocardial infarct |
| 7 | H123 | CTRL | 78 | M | 7.5 | E2/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Ruptured aortic aneurysm |
| 8 | H103 | CTRL | 70 | M | 5 | E3/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Myocardial infarct |
| 9 | H79 | CTRL | 75 | M | 11 | E3/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Myocardial infarct |
| 10 | H77 | CTRL | 75 | M | 3.4 | E3/E4 | n.d. | 0 | n.d. | n.d. | Neg. | Aortic aneurysm |
| 11 | H241 | CTRL | 76 | F | 12 | E3/E4 | n.d. | 0 | n.d. | n.d. | Neg. | Metastatic bowel cancer |
| 12 | H190 | CTRL | 72 | F | 19 | E3/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Ruptured myocardial infarct |
| 13 | H181 | CTRL | 78 | F | 20 | E3/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Aortic aneurysm |
| 14 | H238 | CTRL | 63 | F | 16 | E3/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Dissecting aortic aneurysm |
| 15 | H164 | CTRL | 73 | M | 13 | E3/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Ischemic heart disease |
| 16 | H152 | CTRL | 79 | M | 18 | E3/E3 | n.d. | 0 | n.d. | n.d. | Neg. | Congestive heart failure |
| 17 | AZ46 | AD | 82 | F | 22 | E4/E4 | 1 | n.d. | 2 | 2 | Neg. | Coronary artery disease |
| 18 | AZ37 | AD | 83 | M | 4 | E3/E4 | 3 | n.d. | 1 | 2 | Pos. | Bronchopneumonia |
| 19 | AZ33 | AD | 65 | M | 20 | E3/E3 | 1 | 7 | 1 | 2 | Neg. | Hypostatic pneumonia |
| 20 | AZ22 | AD | 81 | F | 2 | E2/E3 | 1 | 10 | 2 | 2 | Pos. | Bronchopneumonia |
| 21 | AZ20 | AD | 72 | F | 3 | n.d. | 3 | 7 | 2 | 3 | Neg. | Cachexia |
| 22 | AZ34 | AD | 74 | F | 18 | n.d. | 2 | 5 | 2 | 2 | Neg. | Bronchopneumonia, breast carcinoma |
| 23 | AZ29 | AD | 76 | F | 20 | n.d. | 2 | n.d. | 2 | 2 | Pos. | pneumonia |
| 24 | AZ32 | AD | 75 | F | 3 | n.d. | 2 | n.d. | 1 | 2 | Neg. | Bronchostatic pneumonia |
| 25 | AZ28 | AD | 75 | F | 8 | n.d. | 1 | 4 | 2 | 2 | Neg. | Pneumonia |
| 26 | AZ23 | AD | 71 | F | 10 | E3/E4 | 1 | 2 | 2 | 2 | Neg. | Bronchopneumonia |
| 27 | AZ38 | AD | 80 | M | 5.5 | E3/E3 | 2 | 17.5 | 2 | 3 | Neg. | Respiratory arrest/ pulmonary edema |
| 28 | AZ39 | AD | 74 | M | 12 | E3/E3 | 1 | 20 | 2 | 2 | Neg. | Sepsis |
| 29 | AZ80 | AD | 77 | M | 4.5 | E3/E4 | 3 | 13 | 3 | 3 | Neg. | Myocardial infarct |
| 30 | AZ90 | AD | 73 | M | 4 | E3/E3 | 3 | n.d. | 3 | 3 | Neg. | Gastrointestinal hemorrhage |
| 31 | AZ43 | AD | 80 | M | 21 | n.d. | 1 | n.d. | 2 | 2 | Neg. | Bronchopneumonia |
| 32 | AZ88 | AD | 83 | M | 21 | E3/E3 | 2 | n.d. | 3 | 3 | Neg. | Pneumonia |
PMT = post‐mortem time; NFT = neurofibrillary tangles; Atrophy and NFT stage = 1, mild; 2, moderate; 3, severe; Neuritic plaque score (CERAD) = 0, absent; 1, sparse; 2, moderate; 3, frequent; Capillary CAA was determined in one slide of the frontal cortex. n.d. = not determined due to technical reasons.