FIGURE 2.

Inflammation, myelin loss and axonal density in the acute phase of EAE. Representative images of spinal cord white matter lesions are shown for controls (A, D, G, J) and Fgfr2^{ind −/−} mice (B, E, H, K). The inflammatory index (A–C) was not different between Fgfr2^{ind −/−} mice and controls (C). There was a trend towards less myelin loss in Fgfr2^{ind −/−} mice in the LFP/PAS staining (p = 0.132) (D–F). Myelin loss as assessed by MBP immunohistochemistry (G–I) and axonal density (J–L) did not differ between Fgfr2^{ind −/−} mice and controls. n = 4, data are presented as mean ±SEM. Bar: 100 µm.