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. 2021 Jan 4;31(2):297–311. doi: 10.1111/bpa.12916

FIGURE 4.

FIGURE 4

Inflammatory cells in the acute and chronic phase of EAE. Representative images of spinal cord white matter lesions are shown in acute phase for controls (A, D, G) and Fgfr2ind −/− mice (B, E, H). The number of CD3(+) T lymphocytes was not different between Fgfr2ind −/− mice and controls (A–C). The number of Mac3(+) cells (D–F) and B220(+) B lymphocytes (G–I) was significantly less in Fgfr2ind −/− mice. Representative images of spinal cord white matter lesions in the chronic phase of EAE are shown for controls (J, M, P) and Fgfr2ind −/− mice (K, N, Q). The number of CD3(+) T lymphocytes (J–L), Mac3(+) macrophages/microglia (M–O) and B220(+) B lymphocytes (P–R) was significantly less in Fgfr2ind −/− mice. n = 4 in acute phase and n = 5 in chronic phase, data are presented as mean ±SEM. *p < 0.05; **p < 0.005. Bar: 100 µm, 20 µm (insert).