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. 2021 Jan 4;31(2):297–311. doi: 10.1111/bpa.12916

FIGURE 6.

FIGURE 6

Oligodendrocyte populations in the acute and chronic phase of EAE. The number of Olig2(+) and NogoA(+) oligodendrocytes in spinal cord white matter lesions are shown for controls (A, D, G, J) and Fgfr2ind −/− mice (B, E, H, K). There were no differences in Olig2(+) (A–C) and NogoA(+) (D–F) oligodendrocyte numbers between controls and Fgfr2ind −/− mice in the acute phase of EAE. The number of Olig2(+) (G–I) and NogoA(+) oligodendrocytes (J–L) was also not different between Fgfr2ind −/− mice and controls in the chronic phase of EAE. n = 4 (acute phase) and n = 5 (chronic phase), data are presented as mean ±SEM. Bar: 100 µm, 20 mm (insert). (M) In the acute phase of EAE, there were no differences in the expression of MBP, PLP and CNPase. (N) In the chronic phase, PLP protein expression was upregulated in Fgfr2ind −/− mice compared with controls, whereas MBP and CNPase expression was not regulated. Representative western blot images are shown with quantification. n = 2–3 in acute phase and n = 3 in chronic phase, data are presented as mean ±SEM. *p < 0.05.