FIGURE 7.

Remyelination inhibitor expression in the acute and chronic phase of EAE. Representative western blots and quantification are shown for the acute and chronic phase of EAE. (A) In the acute phase of EAE there were no differences in remyelination inhibitor LINGO‐1 and SEMA3A expression between Fgfr2^{ind −/−} mice and controls. Interestingly, remyelination inhibitor TGF‐β expression was less in Fgfr2^{ind −/−} mice. (B) In the chronic phase Fgfr2^{ind −/−} mice showed less expression of remyelination inhibitors SEMA3A and TGF‐β. LINGO‐1 expression was not regulated in the chronic phase of EAE. n = 2–3 in acute phase and n = 3 in chronic phase, data are presented as mean ±SEM. *p < 0.05; **p < 0.005.