Figure 6.

Integrity of the BBB and pericyte numbers in the frontal WM in a nonhuman primate model of cerebral hypoperfusion. A. Box plots showing mean vascular density (% COL4 stained area) in the frontal WM of adult baboons subjected to 3VO. Each time point represents mean of n = 4–8 animals and the results were computed from both hemispheres. There were no differences between the right and left sides. Microvascular density was not changed after 3VO compared to Sham operated animals (P > 0.05). B. Quantification of pericytes density and fibrinogen reactivity in the frontal WM of adult baboons subjected to 3VO. There was a high variation in fibrinogen immunoreactivity over survival time (P < 0.01). Fibrinogen immunoreactivity was the highest at 14 days after 3VO compared to Sham, 1 and 28 days after 3VO groups (*P < 0.05), concomitant with relatively lower pericyte density at 14 days.