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. 2019 Nov 6;30(3):495–514. doi: 10.1111/bpa.12798

Figure 1.

Figure 1

C3aRa administration reverses the expression of myelin‐associated proteins in the PWM of postnatal rats at 14 and 28 days after LPS injection. A–F. Immunohistochemistry (IHC) of CNPase expression in the PWM in postnatal rats at 14 and 28 days after LPS (B, E) or LPS + C3aRa (C, F) injection and their corresponding controls (A, D) at the magnification of ×10 (n = 5) (the area outlined with dotted line). G. Western blot analysis of PLP, MBP, CNPase and MAG protein expression levels in the PWM of postnatal rats at 14 and 28 days after LPS or LPS + C3aRa injection and their corresponding controls. β‐actin served as the loading control (n = 6). H–K. Bar graphs depicting the optical density of CNPase, PLP, MBP and MAG expression shown in G (n = 6). For statistical analysis, two‐way ANOVA with Tukey's post hoc test was used for H, I, J and K and presented as the mean ± standard error of measurement (SEM). Scale bars: 100 μm. *P < 0.05, **P < 0.01.