Table 2.
Univariate Cox proportional hazards regression models of clinical characteristics.
| Variables | PFS | OS | ||
|---|---|---|---|---|
| HR (95% CI) | P‐value | HR (95% CI) | P‐value | |
| Age | 1.036 (1.006‐1.066) | 0.018 | 1.037 (1.007‐1.067) | 0.015 |
| Gender | ||||
| Male | 1 | 1 | ||
| Female | 1.019 (0.573‐1.811) | 0.950 | 1.031 (0.561‐1.894) | 0.923 |
| Histological grade | ||||
| Diffuse astrocytoma (Grade II) | 1 | 1 | ||
| Anaplastic astrocytoma (Grade III) | 4.187 (2.256‐7.771) | <0.0001 | 5.723 (2.985‐10.975) | <0.0001 |
| Location | ||||
| Hemisphere | 1 | 0.192 | 1 | 0.212 |
| Cerebellum | 0.000047*, * | 0.980 | 0.00013*, * | 0.979 |
| Midline | 2.036 (0.945‐4.384) | 0.069 | 2.086 (0.921‐4.725) | 0.078 |
| Extent of resection | ||||
| Total resection | 1 | 1 | ||
| Non‐total resection | 1.048 (0.533‐2.064) | 0.891 | 1.412 (0.722‐2.761) | 0.313 |
| Radiotherapy | ||||
| Yes | 1 | 1 | ||
| No | 1.042 (0.411‐2.644) | 0.931 | 0.944 (0.336‐2.656) | 0.914 |
| Chemotherapy | ||||
| Yes | 1 | 1 | ||
| No | 0.706 (0.279‐1.785) | 0.462 | 0.810 (0.318‐2.064) | 0.659 |
| Chemo‐radiotherapy | ||||
| Yes | 1 | 1 | ||
| No | 0.685 (0.290‐1.613) | 0.386 | 0.653 (0.256‐1.662) | 0.371 |
*
The hazard ratio did not have significance.
Abbreviation: n = number of cases with data available.