Table 4.
Multivariate Cox proportional hazards regression models of clinico‐pathological features and risk groups.
| Variables | PFS | OS | ||
|---|---|---|---|---|
| HR (95% CI) | P‐value | HR (95% CI) | P‐value | |
| Age | 1.024 (0.994‐1.055) | 0.122 | 1.024 (0.992‐1.057) | 0.146 |
| Histological grade | ||||
| Diffuse astrocytoma (Grade II) | 1 | 1 | ||
| Anaplastic astrocytoma (Grade III) | 3.079 (1.601‐5.918) | 0.0007 | 4.268 (2.145‐8.895) | 0.00005 |
| Location | ||||
| Hemisphere | 1 | 0.135 | 1 | 0.145 |
| Cerebellum | 0.00004*, * | 0.975 | 0.00003*, * | 0.984 |
| Midline | 2.304 (1.018‐5.216) | 0.045 | 2.434 (1.002‐5.911) | 0.049 |
| Extent of resection | ||||
| Total resection | 1 | 1 | ||
| Non‐total resection | 1.009 (0.498‐2.044) | 0.980 | 1.291 (0.646‐2.582) | 0.469 |
| Risk group | ||||
| Low‐risk group | 1 | 0.009 | 1 | 0.004 |
| High‐risk group | 3.642 (1.587‐8.359) | 0.002 | 4.667 (1.890‐11.521) | 0.0008 |
| Intermediate‐risk group | 1.988 (0.972‐4.065) | 0.060 | 2.378 (1.090‐5.189) | 0.030 |
*
The hazard ratio did not have significance.
Abbreviation: n = number of cases with data available.