Table 3.

Possible future classification for pediatric‐type glial/glioneuronal tumors, which could be used in a matrix approach to an integrated diagnosis (see Table 2). TKD = tyrosine kinase domain. NOS = not otherwise specified.

Genetically defined

BRAF V600E‐mutant

BRAF fusion‐positive

FGFR1 TKD‐duplicated

FGFR1‐mutant

FGFR1 fusion‐positive

FGFR2 fusion‐positive

MYB‐altered

MYBL1‐altered

NTRK fusion‐positive

Histologically defined

Astrocytoma

Oligodendroglioma

Angiocentric glioma

Ganglioglioma

Dysembryoplastic neuroepithelial tumor

Rosette‐forming glioneuronal tumor

Polymorphous low‐grade neuroepithelial tumor of the young (PLNTY)

Glial/glioneuronal tumor, NOS