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. 2019 Nov 17;30(3):524–540. doi: 10.1111/bpa.12800

Figure 6.

Figure 6

Potential axonal Syt7 transport deficiency. A. Fewer phosphorylated neurofilaments are present in gray and WM‐lesion areas than in corresponding controls. Relating Syt7‐stained areas to the area of phosphorylated neurofilaments (SMI31 positive) gives a very low quotient for MS NAWM and chronic white matter lesions (B). Referencing the immunoreactivity of SMI31 to the immunoreactivity of neurofilaments also gives the impression of hyper‐phosphorylation of the existing axonal structures compared to healthy control tissue (C). The SMI31 / Syt7 / Neurofilament stained area was assessed by ImageJ®. Mean values are shown + SEM. *P < 0.05; **P < 0.01. The point of reference for the statistical analysis (Mann–Whitney rank sum test) was always the corresponding control tissue of the white or GM of healthy controls (subpial controls: n = 12, MS NAGM (subpial): n = 8, subpial lesions: n = 15, leucocortical controls: n = 12, MS NAGM (leucocortical): n = 10, leucocortical lesions: n = 12, control WM: n = 12, MS NAWM: n = 13, chronic WM lesions: n = 13.