Skip to main content
. 2020 Jul 13;30(6):1041–1055. doi: 10.1111/bpa.12872

Figure 5.

Figure 5

SAFB1 expression is unaltered in the dystrophic Purkinje cells of MS patients. Cerebellar Purkinje cells in patients with MS immunostained for SAFB1 (representative images from n = 4 patients, scale bar is 25 µm). SAFB1 staining within Purkinje cells with a typically dystrophic phenotype is nuclear without immunoreactivity in the cytoplasm of the cell soma or dendrites. The percentage of Purkinje cells positive for SAFB1 staining in the nucleus in each patient group is as follows (mean ± SEM); Control (72.2 ± 5.6), MS (83.3 ± 10.7), SCA (77.1 ± 8.6). The percentage of Purkinje cells positive for SAFB1 in the cytoplasm per group is as follows; Control (1.4 ± 0.6), MS (5.1 ± 1.9) SCA (46.2 ± 11.3).