Table 2. MICs (µg/mL) of dorzolamide and gentamicin tested alone and in combination against VRE clinical isolates.

VREstrain	MIC (µg/mL)				FICIa	Interaction*
	Dorzolamide		Gentamicin
	Alone	Combined with gentamicin	Alone	Combined with dorzolamide
E. faecium NR-31912	4	1	64	16	0.50	SYN
E. faecium NR-31915	4	1	16	4	0.50	SYN
E. faecium NR-31916	4	2	32	4	0.63	ADD
E. faecalis NR-31971	4	1	256	32	0.38	SYN
E. faecalis NR-31972	2	1	512	64	0.63	ADD
E. faecalis HM-934	4	1	64	4	0.31	SYN
E. faecalis HM-201	4	2	512	32	0.56	ADD
E. faecalis HM-335	2	1	512	16	0.53	ADD
E. faecium HM-968	4	2	128	2	0.52	ADD
E. faecium HM-970	4	2	32	4	0.63	ADD

Notes.

^aFICI, fractional inhibitory concentration index

^*FICI < 0.5 was considered synergistic (SYN); 0.5 < FICI ≤ 1.25 was considered additive (ADD); 1.25 < FICI ≤ 4 was considered indifferent; FICI > 4 was considered antagonistic.