Figure 2. Interaction network and analysis of the hub genes.

(A) PPI network constructed with the DEGs. The blue points represent upregulated genes screened on the basis of fold change > 1.0 and a corrected P-value of < 0.05. The red points represent downregulation of the expression of genes screened on the basis of fold change <1.0 and a corrected P-value of < 0.05. (B) The most significant module was obtained from PPI network with 16 nodes and 114 edges. (C) The hub genes were identified using Cytoscape. (D) The biological process analysis of hub genes was performed using the BiNGO plug-in, ∗p < 0.05. Different colors of nodes refer to the functional annotation of ontologies.