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. 2021 Mar 30;9:e11145. doi: 10.7717/peerj.11145

Table 1. Significantly enriched GO terms of the common DEGs (BP, biological process; CC, cellular component; DEG, differentially expressed gene; GO, Gene Ontology; MF, molecular function).

Gene symbol Full name Function
MMP9 Matrix Metallopeptidase 9 Pathways: IL-17 Family Signaling Pathways and TNF signaling pathway; GO: endopeptidase activity and hydrolase activity.
VWF Von Willebrand Factor Pathways: RET signaling and Complement and coagulation cascades; GO: immunoglobulin binding and collagen binding.
PECAM1 Platelet And Endothelial Cell Adhesion Molecule 1 Pathways: NF-kappaB Signaling and Innate Immune System; GO:protein binding and protein homodimerization activity
CD34 CD34 Molecule Pathways: NF-kappaB Signaling and Cell adhesion molecules (CAMs);GO: transcription factor binding and carbohydrate binding.
COL1A1 Collagen Type I Alpha 1 Chain Pathways: VEGF Signaling Pathway and ERK Signaling; GO: extracellular matrix structural constituent and extracellular matrix structural constituent conferring tensile strength.
SPP1 Secreted Phosphoprotein 1 Pathways: ERK Signaling and TGF-beta Receptor Signaling; GO: cytokine activity and integrin binding.
TIMP1 TIMP Metallopeptidase Inhibitor 1 Pathways: GPCR Pathway and CREB Pathway; GO: enzyme inhibitor activity and peptidase inhibitor activity
EDN1 Endothelin 1 Pathways: RET signaling and TNF signaling pathway; GO: cytokine activity and signaling receptor binding.
PPARG Peroxisome Proliferator Activated Receptor Gamma Pathways: AMP-activated Protein Kinase (AMPK) Signaling and PPAR signaling pathway; GO: activating transcription factor binding and DNA-binding transcription factor activity.
CAV1 Caveolin 1 Pathways: RET signaling and ALK1 signaling events ; GO: peptidase activator activity and patched binding.