| Drug 1 | |
| Generic/Working Name | Afatinib |
| Drug Type | Small molecule |
| Drug Class | Her‐2 / Neu |
| Dose | 20 milligrams (mg) per flat dose |
| Route | Oral (p.o.) |
| Schedule of Administration | The RP2D was 20 mg afatinib QD and 25 mg selumetinib b.i.d. (21 days on/7 days off) for continuous afatinib dosing and for intermittent dosing with both drugs 5 days on/2 days off |
| Drug 2 | |
| Generic/Working Name | Selumetinib |
| Drug Type | Small molecule |
| Drug Class | MEK |
| Dose | 25 milligrams (mg) per flat dose |
| Route | Oral (p.o.) |
| Schedule of Administration | The RP2D was 20 mg afatinib QD and 25 mg selumetinib b.i.d. (21 days on/7 days off) for continuous afatinib dosing and for intermittent dosing with both drugs 5 days on/2 days off |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.