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| Dose level | Dose of drug: afatinib | Dose of drug: selumetinib | Number enrolled | Number evaluable for toxicity |
|---|---|---|---|---|
| 1 | 20 mg QD | 25 mg b.i.d. (21 days on/7 days off) | 6 | 6 |
| 2 | 20 mg QD | 50 mg b.i.d. (21 days on/7 days off) | 5 | 5 |
| 3 | 30 mg QD | 25 mg b.i.d. (21 days on/7 days off) | 4 | 4 |
| 4 | 30 mg QD (5 days on/2 days off) | 25 mg b.i.d. (5 days on/2 days off) | 2 | 2 |
| 5 | 20 mg QD (5 days on/2 days off) | 25 mg b.i.d. (5 days on/2 days off) | 5 | 5 |
Abbreviation: QD, once daily.
