All phases, All cycles				Grade			Total
	NC/NA, %	1	2	3	4	5
Ipilimumab 3 mg/kg (n = 11), n (%)
Pruritus	55	3 (27.3)	2 (18.2)	0	0	0	5 (45.5)
Rash	55	3 (27.3)	2 (18.2)	0	0	0	5 (45.5)
Aspartate aminotransferase increased	64	3 (27.3)	1 (9.1)	0	0	0	4 (36.4)
Constipation	64	1 (9.1)	3 (27.3)	0	0	0	4 (36.4)
Cough	64	3 (27.3)	1 (9.1)	0	0	0	4 (36.4)
Malignant neoplasm progression	64	0	0	0	0	4 (36.4)	4 (36.4)
Weight decreased	64	2 (18.2)	2 (18.2)	0	0	0	4 (36.4)
Anemia	73	0	3 (27.3)	0	0	0	3 (27.3)
Decreased appetite	73	2 (18.2)	1 (9.1)	0	0	0	3 (27.3)
Nausea	73	3 (27.3)	0	0	0	0	3 (27.3)
Asthenia	82	2 (18.2)	0	0	0	0	2 (18.2)
Blood lactate dehydrogenase	82	0	2 (18.2)	0	0	0	2 (18.2)
Dizziness	82	2 (18.2)	0	0	0	0	2 (18.2)
Hypokalemia	82	0	0	2 (18.2)	0	0	2 (18.2)
Hyponatremia	82	0	0	1 (9.1)	1 (9.1)	0	2 (18.2)
Hypoproteinemia	82	1 (9.1)	1 (9.1)	0	0	0	2 (18.2)
Pain	82	1 (9.1)	1 (9.1)	0	0	0	2 (18.2)
Pyrexia	82	2 (18.2)	0	0	0	0	2 (18.2)
Vomiting	82	1 (9.1)	1 (9.1)	0	0	0	2 (18.2)
Abdominal pain	91	0	1 (9.1)	0	0	0	1 (9.1)
Alanine aminotransferase increased	91	0	1 (9.1)	0	0	0	1 (9.1)
Blood alkaline phosphatase increased	91	1 (9.1)	0	0	0	0	1 (9.1)
Blood creatinine increased	91	1 (9.1)	0	0	0	0	1 (9.1)
Chest discomfort	91	1 (9.1)	0	0	0	0	1 (9.1)
Chest pain	91	0	1 (9.1)	0	0	0	1 (9.1)
Dreamy state	91	1 (9.1)	0	0	0	0	1 (9.1)
Electrocardiogram QT prolonged	91	1 (9.1)	0	0	0	0	1 (9.1)
Emotional disorder	91	0	1 (9.1)	0	0	0	1 (9.1)
Fatigue	91	1 (9.1)	0	0	0	0	1 (9.1)
Flushing	91	1 (9.1)	0	0	0	0	1 (9.1)
Gamma‐glutamyltransferase increased	91	0	1 (9.1)	0	0	0	1 (9.1)
Gastrointestinal disorder	91	1 (9.1)	0	0	0	0	1 (9.1)
Hyperkalemia	91	0	1 (9.1)	0	0	0	1 (9.1)
Hyperthyroidism	91	1 (9.1)	0	0	0	0	1 (9.1)
Hypothyroidism	91	0	1 (9.1)	0	0	0	1 (9.1)
Insomnia	91	0	1 (9.1)	0	0	0	1 (9.1)
Mouth ulceration	91	1 (9.1)	0	0	0	0	1 (9.1)
Neurotoxicity	91	1 (9.1)	0	0	0	0	1 (9.1)
Otitis media	91	1 (9.1)	0	0	0	0	1 (9.1)
Pain in extremity	91	0	1 (9.1)	0	0	0	1 (9.1)
Pigmentation disorder	91	0	1 (9.1)	0	0	0	1 (9.1)
Platelet count increased	91	1 (9.1)	0	0	0	0	1 (9.1)
Pneumonia	91	0	1 (9.1)	0	0	0	1 (9.1)
Productive cough	91	1 (9.1)	0	0	0	0	1 (9.1)
Pruritus generalised	91	1 (9.1)	0	0	0	0	1 (9.1)
Skin disorder	91	0	1 (9.1)	0	0	0	1 (9.1)
Skin exfoliation	91	0	1 (9.1)	0	0	0	1 (9.1)
Somnolence	91	1 (9.1)	0	0	0	0	1 (9.1)
Tachypnoea	91	0	1 (9.1)	0	0	0	1 (9.1)
Thyroid disorder	91	1 (9.1)	0	0	0	0	1 (9.1)
Urine abnormality	91	0	1 (9.1)	0	0	0	1 (9.1)