Figure 5.

Prophylactic CMFG intervention alters the gut microbial composition and SCFAs production. A) Shannon index of OTU level. B) Sobs index of OTU level. C-E) PCoA plots assessed by Adonis analysis among these groups at day 0, at day 3, and at day 7, respectively. F) shows the relative abundance of microbial OTUs, classified at the phylum and genus level, in different groups. Linear discriminate analysis effect size (LEfSe) was performed to determine the difference in abundance at day 0 (g), day 3 (h), and at day 7 (i). SCFAs concentrations from feces among Vehicle, DSS, and CMFG + DSS groups are shown in J (acetate), K (propionate) and L (butyrate). Asterisks denote significant differences (*p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001), n = 6 per group, data are represented as mean ± SEM