Table 1.
Dopamine Substitution Enhancing Effects of Various Kinds of Uptake Inhibitors
| MPTP Model (Monotherapy) | MPTP Model (Plus l-Dopa) | Clinical Study | |
|---|---|---|---|
| Inhibition of dopamine reuptake | |||
| SEP-22,8791 | + | ||
| Vanoxerine | + | ||
| Inhibition of dopamine and norepinephrine reuptake | |||
| Brasofensine | + | + | |
| Bupropion | + | ||
| Nomofensine | + | + | |
| Methylphenidate | – | – | + |
| Inhibition of dopamine and serotonin reuptake | |||
| MDMA | + | ||
| UWA-101 | + | ||
| UWA-121 | + | ||
| Monoamine uptake inhibitors | |||
| BTS-74,398 | + | ||
| Tesofensine | ± | ||
| SMe1EC2M3 | |||
Notes: +, positive response as dopamine substituting compound; –, negative response as dopamine transmission enhancing drug; empty field, no study was performed.