Figure 5.

Model depicting the regulation of cell proliferation by ∆40p53 through miR-186-5p-YY1 axis

(A) In absence of ∆40p53, miR-186-5p levels do not increase which leads to higher YY1 levels resulting in increased cell proliferation. (B) However, when ∆40p53 is present it upregulates miR-186-5p levels probably through direct transcriptional activation or through precursor miRNA processing. Upregulated miR-186 then targets 3'UTR of YY1 leading to its decreased levels which ultimately leads to a reduction in proliferation.