Table 4.

Comparison of svPPA with healthy controls and AD on MTL subregional volumes (in mm³; parahippocampal subregions are corrected for slice number; ICV is regressed out for all variables)

	svPPA	Control	svPPA	svPPA vs Control	AD	AD	svPPA vs AD	AD vs Control
Left	Mean±SD	Mean±SD	% of Control	p-value	Mean±SD	% of Control	p-value	p-value
N	12	23			36
CA1	831±129	1328±126	−37.4	<0.001	1043±219	−21.5	0.002	<0.001
DG	612±72	826±107	−25.9	<0.001	664±119	−19.7	0.068	<0.001
SUB	370±44	436±44	−15.2	<0.001	390±69	−10.7	0.220	0.012
ERC	15.7±3.4	21.1±2.5	−25.9	<0.001	18.8±4.2	−11.3	0.032	0.012
BA35	9.8±3.9	21.2±4.0	−53.8	<0.001	16.3±4.8	−23.3	<0.001	<0.001
BA36	33.0±10.6	71.5±12.2	−53.8	<0.001	63.2±17.4	−11.6	<0.001	0.076
PHC	42.1±9.1	55.3±9.6	−23.9	0.001	45.4±9.4	−17.9	0.283	0.001
Right	Mean±SD	Mean±SD	% of Control	p-value	Mean±SD	% of Control	p-value	p-value
N	14	23			37
CA1	1157±208	1399±138	−17.3	<0.001	1133±210	−19.0	0.626	<0.001
DG	747±126	851±94	−12.2	0.010	666±109	−21.7	0.049	<0.001
SUB	403±50	438±42	−8.1	0.033	393±72	−10.4	0.535	0.003
ERC	19.4±4.8	22.2±3.4	−12.6	0.062	19.6±3.8	−11.9	0.916	0.011
BA35	16.9±5.9	21.3±2.6	−20.6	0.002	17.6±4.5	−17.4	0.447	0.001
BA36	46.3±16.4	69.4±11.7	−33.2	<0.001	64.8±17.2	−6.6	0.002	0.194
PHC	56.5±12.9	62.2±9.7	−9.2	0.156	49.7±11.5	−20.2	0.083	<0.001

^*Bolded p-values are significant after the Holm-Bonferroni correction. svPPA=semantic variant Primary Progressive Aphasa; AD=Alzheimer’s disease; CA=cornu ammonis; DG=dentate gyrus; SUB=subiculum; ERC=entorhinal cortex; BA=Brodmann area; PHC=parahippocampal cortex