Figure 1.

Potential mechanism on phosphoglycerate mutase 1 (PGAM1)-mediated DNA damage repair regulation

Schematic overview of the proposed mechanism on PGAM1-mediated DNA damage repair pathway regulation through wild-type p53-induced phosphatase 1 (WIP1) binding in the cytoplasm. Overexpressed PGAM1 in gliomas binds to the cytoplasmic phosphatase WIP1 and counteracts the latter’s translocation to the cell nucleus where it would normally dephosphorylate the ataxia-telangiectasia mutated (ATM) signaling pathway. When PGAM1 expression is genetically inhibited, WIP1 is allowed to enter the nucleus and deactivate the ATM signaling pathway which in turn increases cellular sensitivity to irradiation (IR) and temozolomide (TMZ) chemotherapy.